2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. 1379761-16-6

1379761-16-6

Aminoxyacetamide-PEG3-azide Chemical Structure

1379761-16-6

Chemical Structure

  • Aminoxyacetamide-PEG3-azide
  • CAS No: 1379761-16-6
    Formula: C10H21N5O5
    Molecular Weight: 291.30
  • IUPAC Name: 2-(aminooxy)-N-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)acetamide
  • InChIKey: XAZLOCGDVCWCCY-UHFFFAOYSA-N
  • SMILES: NOCC(NCCOCCOCCOCCN=[N+]=[N-])=O

Biological Activity: Aminoxyacetamide-PEG3-azide is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminoxyacetamide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No. Product Name Purity Description
HY-133434 Aminoxyacetamide-PEG3-azide Aminoxyacetamide-PEG3-azide is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Aminoxyacetamide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Keywords:

Aminoxyacetamide-PEG3-azide