3028674-29-2

Chemical Structure

PRMT5-MTA-IN-3
CAS No: 3028674-29-2

Formula: C₁₉H₁₇F₃N₆O₃

Molecular Weight: 434.37
InChIKey: NRMCEBWFKRDAIS-CYBMUJFWSA-N
SMILES: CN1N=CC2=C1C(N)=NC=C2NC(C(N([C@@H]3COC4=CC(C(F)(F)F)=CC=C43)C)=O)=O

Biological Activity: PRMT5-MTA-IN-3 (Compound P2A) is an orally active and selective protein arginine methyltransferase 5 (PRMT5) inhibitor. PRMT5-MTA-IN-3 inhibits cell proliferation in the MTAP-deficient colorectal cancer HCT - 116 cell line with an IC₅₀ value of 5 nM. PRMT5-MTA-IN-3 is promising for research of cancers, especially for MTAP-deficient tumors, such as colorectal cancer, non-small cell lung cancer, pancreatic cancer^[1].

Cat. No.	Product Name	Purity	Description
HY-172733	PRMT5-MTA-IN-3		PRMT5-MTA-IN-3 (Compound P2A) is an orally active and selective protein arginine methyltransferase 5 (PRMT5) inhibitor. PRMT5-MTA-IN-3 inhibits cell proliferation in the MTAP-deficient colorectal cancer HCT - 116 cell line with an IC₅₀ value of 5 nM. PRMT5-MTA-IN-3 is promising for research of cancers, especially for MTAP-deficient tumors, such as colorectal cancer, non-small cell lung cancer, pancreatic cancer.

References

[1]. Liu B, et al. Prmt5-mta inhibitor. WO2024152973A1. 2024-07-25.

Keywords:

PRMT5-MTA-IN-3

Name
Email *

	Sorry, but the email address you supplied was invalid.