2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. 2410534-62-0

2410534-62-0

DC-U4106 Chemical Structure

2410534-62-0

Chemical Structure

  • DC-U4106
  • CAS No: 2410534-62-0
    Formula: C29H27N5O5
    Molecular Weight: 525.56
  • IUPAC Name: 8-((3,5-dimethyl-1H-pyrazol-4-yl)oxy)-5,7-dihydroxy-2-(4-(4-(pyridin-2-yl)piperazin-1-yl)phenyl)-4H-chromen-4-one
  • InChIKey: VNWOJNLRTJFWRQ-UHFFFAOYSA-N
  • SMILES: O=C1C=C(C2=CC=C(N3CCN(C4=NC=CC=C4)CC3)C=C2)OC5=C1C(O)=CC(O)=C5OC6=C(C)NN=C6C

Biological Activity: DC-U4106 is a USP8 targeting inhibitor with the Kdvalue of 4.7 μM and the IC50 value of 1.2 μM. DC-U4106 can target the ubiquitin pathway and facilitate the degradation of Erα. DC-U4106 inhibits tumor growth with minimal toxicity and has the potential for the research of breast cancer[1].

Cat. No. Product Name Purity Description
HY-150505 DC-U4106 99.03% DC-U4106 is a USP8 targeting inhibitor with the Kdvalue of 4.7 μM and the IC50 value of 1.2 μM. DC-U4106 can target the ubiquitin pathway and facilitate the degradation of Erα. DC-U4106 inhibits tumor growth with minimal toxicity and has the potential for the research of breast cancer.

References

[1]. Yucheng Tian, et al. Discovery of Potent Small-Molecule USP8 Inhibitors for the Treatment of Breast Cancer through Regulating ERα Expression. J Med Chem. 2022 Jul 5. [Content Brief]

Keywords:

DC-U4106