2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. 444300-74-7

444300-74-7

Argyrin F Chemical Structure

444300-74-7

Chemical Structure

  • Argyrin F
  • CAS No: 444300-74-7
    Formula: C40H44N10O9S
    Molecular Weight: 840.90
  • InChIKey: FJSMXOTZGJRIEU-GZAHMLPMSA-N
  • SMILES: COC1=C2C(C[C@@H]3NC([C@@H](NC(C4=CSC([C@H](NC(CN(C(C(NC([C@H](NC(CNC3=O)=O)C)=O)=C)=O)C)=O)CO)=N4)=O)CC5=CNC6=CC=CC=C56)=O)=CNC2=CC=C1

Biological Activity: Argyrin F a cyclic peptide with antitumoral activities. Argyrin F inhibits cell proliferation, migration, invasion and colony formation by partial induction of apoptosis and epithelial-mesenchymal transition (EMT). Argyrin F stabilizes p27kip, up-regulated p21waf1/cip1 and depletes COX2. Argyrin F can be used for the study of pancreatic ductal adenocarcinoma (PDAC)[1].

Cat. No. Product Name Purity Description
HY-N13944 Argyrin F Argyrin F a cyclic peptide with antitumoral activities. Argyrin F inhibits cell proliferation, migration, invasion and colony formation by partial induction of apoptosis and epithelial-mesenchymal transition (EMT). Argyrin F stabilizes p27kip, up-regulated p21waf1/cip1 and depletes COX2. Argyrin F can be used for the study of pancreatic ductal adenocarcinoma (PDAC).

References

[1]. Chen X, et al. Therapeutic effects of Argyrin F in pancreatic adenocarcinoma. Cancer Lett. 2017 Jul 28;399:20-28. [Content Brief]

Keywords:

Argyrin F