2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. 1394615-06-5

1394615-06-5

HDAC6-IN-35 Chemical Structure

1394615-06-5

Chemical Structure

  • HDAC6-IN-35
  • CAS No: 1394615-06-5
    Formula: C22H25ClN2O2
    Molecular Weight: 384.90
  • InChIKey: PXEZPNSVZXAZJQ-UHFFFAOYSA-N
  • SMILES: O=C1CC2(CN1)CCN(CC2)CC3=CC=CC(OCC4=CC=CC=C4Cl)=C3

Biological Activity: HDAC6-IN-35 (compound C4 (ZINC000077541942)) is a potent and BBB-penetrated HDAC6 inhibitor with the IC50 of 4.7 μM. HDAC6-IN-35 shows cell toxicity against MDA-MB-231 with EC50 of 40.6 μM[1].

Cat. No. Product Name Purity Description
HY-163369 HDAC6-IN-35 HDAC6-IN-35 (compound C4 (ZINC000077541942)) is a potent and BBB-penetrated HDAC6 inhibitor with the IC50 of 4.7 μM. HDAC6-IN-35 shows cell toxicity against MDA-MB-231 with EC50 of 40.6 μM.

References

[1]. Uba AI, et al. Discovery of novel inhibitors of histone deacetylase 6: Structure-based virtual screening, molecular dynamics simulation, enzyme inhibition and cell viability assays. Life Sci. 2024;338:122395. [Content Brief]

Keywords:

HDAC6-IN-35