2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. 1286770-55-5

1286770-55-5

Verubecestat Chemical Structure

1286770-55-5

Chemical Structure

  • Verubecestat
  • Synonym(s): MK-8931
  • CAS No: 1286770-55-5
    Formula: C17H17F2N5O3S
    Molecular Weight: 409.41
  • IUPAC Name: (R)-N-(3-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide
  • InChIKey: YHYKUSGACIYRML-KRWDZBQOSA-N
  • SMILES: O=C(C1=NC=C(F)C=C1)NC2=CC=C(F)C([C@@](C3)(C)N=C(N)N(C)S3(=O)=O)=C2

Biological Activity: Verubecestat (MK-8931) is an orally active, high-affinity BACE1 and BACE2 inhibitor with Ki values of 2.2 nM and 0.38 nM. Verubecestat effectively reduces Aβ40 and has the potential for Alzheimer's Disease[1][2].

Cat. No. Product Name Purity Description
HY-16759 Verubecestat 99.56% Verubecestat (MK-8931) is an orally active, high-affinity BACE1 and BACE2 inhibitor with Ki values of 2.2 nM and 0.38 nM. Verubecestat effectively reduces Aβ40 and has the potential for Alzheimer's Disease.

References

[1]. Scott JD, et al. Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer'sDisease. Med Chem. 2016 Dec 8;59(23):10435-10450. [Content Brief]
[2]. Yan R, et al. Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs. Transl Neurodegener. 2016 Jul 14;5:13. [Content Brief]

Keywords:

Verubecestat