2. Anti-infection
  3. Fungal
  4. 171179-37-6

171179-37-6

BPIQ-II hydrochloride Chemical Structure

171179-37-6

Chemical Structure

  • BPIQ-II hydrochloride
  • Synonym(s): PD 158294
  • CAS No: 171179-37-6
    Formula: C15H11BrClN5
    Molecular Weight: 376.64
  • IUPAC Name: N-(3-bromophenyl)-1H-imidazo[4,5-g]quinazolin-8-amine hydrochloride
  • InChIKey: FENLVGDZGJBHPT-UHFFFAOYSA-N
  • SMILES: BrC1=CC(NC2=NC=NC3=C2C=C4NC=NC4=C3)=CC=C1.Cl

Biological Activity: BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50=8 pM). It is selective for EGFR over an assortment of other tyrosine and serine/threonine kinases. Cellular studies indicate that BPIQ-II can enter cells and very selectively shut down EGF-stimulated signal transmission by binding competitively at the ATP site of EGFR.

Cat. No. Product Name Purity Description
HY-120857 BPIQ-II hydrochloride BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50=8 pM). It is selective for EGFR over an assortment of other tyrosine and serine/threonine kinases. Cellular studies indicate that BPIQ-II can enter cells and very selectively shut down EGF-stimulated signal transmission by binding competitively at the ATP site of EGFR.

Keywords:

BPIQ-II hydrochloride