2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. PI3K Wnt
  4. 1448711-61-2

1448711-61-2

PI3Kα-IN-16 Chemical Structure

1448711-61-2

Chemical Structure

  • PI3Kα-IN-16
  • CAS No: 1448711-61-2
    Formula: C27H24N2O2
    Molecular Weight: 408.49
  • InChIKey: CCPVJNGJNZLMDG-UHFFFAOYSA-N
  • SMILES: CCN1C2=CC=CC=C2C3=C1C(C4=CC=CC5=C4C=CC=C5)=NC(C(OC(C)C)=O)=C3

Biological Activity: PI3Kα-IN-16 (Z86) is a novel PI3Kα inhibitor with an IC50 value of 4.28 μM. PI3Kα-IN-16 has potent inhibitory efficiency on PI3K-mediated CRCs growth and migration. PI3Kα-IN-16 also inhibits the Wnt signaling pathway[1].

Cat. No. Product Name Purity Description
HY-161140 PI3Kα-IN-16 PI3Kα-IN-16 (Z86) is a novel PI3Kα inhibitor with an IC50 value of 4.28 μM. PI3Kα-IN-16 has potent inhibitory efficiency on PI3K-mediated CRCs growth and migration. PI3Kα-IN-16 also inhibits the Wnt signaling pathway.

References

[1]. Nie S, et al. β-carboline derivative Z86 attenuates colorectal cancer cell proliferation and migration by directly targeting PI3K. Nat Prod Bioprospect. 2024 Jan 3;14(1):3. [Content Brief]

Keywords:

PI3Kα-IN-16