2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. 1449473-97-5

1449473-97-5

PF-06305591 Chemical Structure

1449473-97-5

Chemical Structure

  • PF-06305591
  • CAS No: 1449473-97-5
    Formula: C15H22N4O
    Molecular Weight: 274.36
  • IUPAC Name: (2R,3S)-3-amino-3-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)-2-methylpropanamide
  • InChIKey: APWZIFIAVVFPNT-PELKAZGASA-N
  • SMILES: CC(C)(C)C1=CC=C(NC([C@H]([C@@H](C)C(N)=O)N)=N2)C2=C1

Biological Activity: PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM. An excellent preclinical in vitro ADME and safety profile[1].

Cat. No. Product Name Purity Description
HY-114301 PF-06305591 99.92% PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM. An excellent preclinical in vitro ADME and safety profile.

References

[1]. Brown AD, et al. The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain. Bioorg Med Chem. 2019 Jan 1;27(1):230-239. [Content Brief]

Keywords:

PF-06305591