2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. 1451272-71-1

1451272-71-1

SBI-425 Chemical Structure

1451272-71-1

Chemical Structure

  • SBI-425
  • CAS No: 1451272-71-1
    Formula: C13H12ClN3O4S
    Molecular Weight: 341.77
  • IUPAC Name: 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide
  • InChIKey: SBAITEDLNTYIOE-UHFFFAOYSA-N
  • SMILES: O=C(C1=CC(NS(=O)(C2=CC(Cl)=CC=C2OC)=O)=CN=C1)N

Biological Activity: SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC50=16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival[1][2].

Cat. No. Product Name Purity Description
HY-124756 SBI-425 98.88% SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC50=16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival.

References

[1]. Pinkerton AB, et al. Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett. 2018 Jan 1;28(1):31-34. [Content Brief]
[2]. Sheen CR, et al. Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification. J Bone Miner Res. 2015 May;30(5):824-36. [Content Brief]

Keywords:

SBI-425