2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. 1159997-27-9

1159997-27-9

AMG9678 Chemical Structure

1159997-27-9

Chemical Structure

  • AMG9678
  • CAS No: 1159997-27-9
    Formula: C20H18F6N2O
    Molecular Weight: 416.36
  • IUPAC Name: (R)-1-(4-(trifluoromethyl)phenyl)-N-((S)-1,1,1-trifluoropropan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide
  • InChIKey: OGMWZDQYXGKSBP-YVEFUNNKSA-N
  • SMILES: O=C(N1CCC2=C(C=CC=C2)[C@H]1C3=CC=C(C(F)(F)F)C=C3)N[C@@H](C)C(F)(F)F

Biological Activity: AMG9678 is a potent, selective, orally active antagonist of TRPM8 with an IC50 of 31.2 nM[1].

Cat. No. Product Name Purity Description
HY-104062 AMG9678 AMG9678 is a potent, selective, orally active antagonist of TRPM8 with an IC50 of 31.2 nM.

References

[1]. Gavva NR, et al. Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation. Mol Pain. 2012 May 9;8:36. [Content Brief]

Keywords:

AMG9678