2. Neuronal Signaling JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. Trk Receptor EGFR Apoptosis
  4. 148741-30-4

148741-30-4

Tyrphostin AG 879 Chemical Structure

148741-30-4

Chemical Structure

  • Tyrphostin AG 879
  • Synonym(s): AG 879
  • CAS No: 148741-30-4
    Formula: C18H24N2OS
    Molecular Weight: 316.46
  • IUPAC Name: (E)-2-cyano-3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enethioamide
  • InChIKey: XRZYELWZLNAXGE-KPKJPENVSA-N
  • SMILES: S=C(N)/C(C#N)=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1

Biological Activity: Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC50 of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity[1][2][3].

Cat. No. Product Name Purity Description
HY-20878 Tyrphostin AG 879 99.85% Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC50 of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity.

References

[1]. Zhou Y, et al. Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis. Cancer Res. 2006 Jan 1;66(1):404-11. [Content Brief]
[2]. Levitzki A, et al. Tyrosine kinase inhibition: an approach to drug development. Science. 1995 Mar 24;267(5205):1782-8. [Content Brief]

Keywords:

Tyrphostin AG 879