2. Natural Products
  3. Plants Terpenoids
  4. Alismataceae Triterpenes
  5. Alisma plantago-aquatica Linn.
  6. 858350-62-6

858350-62-6

AR244555 Chemical Structure

858350-62-6

Chemical Structure

  • AR244555
  • CAS No: 858350-62-6
    Formula: C23H23ClF2N2O
    Molecular Weight: 416.89
  • IUPAC Name: (1'-(but-3-en-1-yl)-5-chlorospiro[indoline-3,4'-piperidin]-1-yl)(2,6-difluorophenyl)methanone
  • InChIKey: QKPSTNGNDWHYCH-UHFFFAOYSA-N
  • SMILES: O=C(N1CC2(CCN(CCC=C)CC2)C3=C1C=CC(Cl)=C3)C4=C(F)C=CC=C4F

Biological Activity: AR244555 is a malate-aspartate shuttle (MAS) inverse agonist with IC50s of 186 nM and 348 nM in human and rat inositol phosphatase (IP) Gq coupling assays respectively. AR244555 has cardioprotective effects[1].

Cat. No. Product Name Purity Description
HY-111273 AR244555 AR244555 is a malate-aspartate shuttle (MAS) inverse agonist with IC50s of 186 nM and 348 nM in human and rat inositol phosphatase (IP) Gq coupling assays respectively. AR244555 has cardioprotective effects.

References

[1]. Tong Zhang, et al. Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection. Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H299-311. [Content Brief]

Keywords:

AR244555