2. Neuronal Signaling Apoptosis
  3. Sigma Receptor Apoptosis
  4. 157752-20-0

157752-20-0

CB-64D Chemical Structure

157752-20-0

Chemical Structure

  • CB-64D
  • CAS No: 157752-20-0
    Formula: C22H23NO2
    Molecular Weight: 333.42
  • IUPAC Name: (1R,5R)-8-((E)-benzylidene)-5-(3-hydroxyphenyl)-2-methyl-2-azabicyclo[3.3.1]nonan-7-one
  • InChIKey: YVMTWTZIAIUURI-VQSNLYSRSA-N
  • SMILES: O=C1C[C@@]2(C3=CC=CC(O)=C3)CCN(C)[C@@](C2)([H])/C1=C\C4=CC=CC=C4

Biological Activity: CB-64D is the agonist for sigma receptor 2 and sigma receptor 1 with Ki of 16.5 and 3063 nM. CB-64D induces apoptosis in cancer cell SK-N-SH[1][2].

Cat. No. Product Name Purity Description
HY-120360 CB-64D CB-64D is the agonist for sigma receptor 2 and sigma receptor 1 with Ki of 16.5 and 3063 nM. CB-64D induces apoptosis in cancer cell SK-N-SH.

References

[1]. Nicholson H, et al., Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor Activity. J Pharmacol Exp Ther. 2015 Aug;354(2):203-12. [Content Brief]
[2]. Bowen WD, et al., CB-64D and CB-184: ligands with high sigma 2 receptor affinity and subtype selectivity. Eur J Pharmacol. 1995 May 24;278(3):257-60. [Content Brief]

Keywords:

CB-64D