2. Immunology/Inflammation
  3. Interleukin Related
  4. 2935587-91-8

2935587-91-8

PROTAC CDK9 degrader-6 Chemical Structure

2935587-91-8

Chemical Structure

  • PROTAC CDK9 degrader-6
  • CAS No: 2935587-91-8
    Formula: C42H49Cl2N9O8
    Molecular Weight: 878.80
  • IUPAC Name: 4-(2,6-dichlorobenzamido)-N-(1-(11-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)undecanoyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide
  • InChIKey: SRUVBNFPTDBESG-UHFFFAOYSA-N
  • SMILES: O=C(NCCCCCCCCCCC(N1CCC(CC1)NC(C2=NNC=C2NC(C3=C(C=CC=C3Cl)Cl)=O)=O)=O)CNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O

Biological Activity: PROTAC CDK9 degrader-6 is a PROTAC targeting to CDK9 sepcifically. PROTAC CDK9 degrader-6 mediates CDK9 degradation via the proteasome. PROTAC CDK9 degrader-6 degrades CDK9 with DC50s of 0.10 μM and 0.14 μM for the CDK942 and CDK955 isoforms, respectively[1].

Cat. No. Product Name Purity Description
HY-149963 PROTAC CDK9 degrader-6 PROTAC CDK9 degrader-6 is a PROTAC targeting to CDK9 sepcifically. PROTAC CDK9 degrader-6 mediates CDK9 degradation via the proteasome. PROTAC CDK9 degrader-6 degrades CDK9 with DC50s of 0.10 μM and 0.14 μM for the CDK942 and CDK955 isoforms, respectively.

References

[1]. Tokarski RJ 2nd, et al. Bifunctional degraders of cyclin dependent kinase 9 (CDK9): Probing the relationship between linker length, properties, and selective protein degradation. Eur J Med Chem. 2023 Jun 5;254:115342. [Content Brief]

Keywords:

PROTAC CDK9 degrader-6