2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. 161611-99-0

161611-99-0

DU125530 Chemical Structure

161611-99-0

Chemical Structure

  • DU125530
  • CAS No: 161611-99-0
    Formula: C23H26ClN3O5S
    Molecular Weight: 491.99
  • IUPAC Name: 2-(4-(4-(7-chloro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperazin-1-yl)butyl)benzo[d]isothiazol-3(2H)-one 1,1-dioxide
  • InChIKey: LYXKFNHUJJDTIA-UHFFFAOYSA-N
  • SMILES: O=C(C1=C2C=CC=C1)N(CCCCN3CCN(C4=C5OCCOC5=CC(Cl)=C4)CC3)S2(=O)=O

Biological Activity: DU125530 is a potent and selective5-HT1A receptor antagonist with Ki values of 0.7, 890, 1200, 240, 750, 1100 nM for 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2C, 5-HT3, respectively. DU125530 shows antidepressant effects[1][2].

Cat. No. Product Name Purity Description
HY-19283 DU125530 DU125530 is a potent and selective5-HT1A receptor antagonist with Ki values of 0.7, 890, 1200, 240, 750, 1100 nM for 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2C, 5-HT3, respectively. DU125530 shows antidepressant effects.

References

[1]. Mos J, et al. The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons. Eur J Pharmacol. 1997 May 1;325(2-3):145-53. [Content Brief]
[2]. Scorza MC, et al. Preclinical and clinical characterization of the selective 5-HT(1A) receptor antagonist DU-125530 for antidepressant treatment. Br J Pharmacol. 2012 Nov;167(5):1021-34. [Content Brief]

Keywords:

DU125530