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  6. 134036-53-6

134036-53-6

AG 370 Chemical Structure

134036-53-6

Chemical Structure

  • AG 370
  • CAS No: 134036-53-6
    Formula: C15H9N5
    Molecular Weight: 259.27
  • IUPAC Name: (E)-2-amino-4-(1H-indol-5-yl)buta-1,3-diene-1,1,3-tricarbonitrile
  • InChIKey: CMMDWEJTQUTCKG-SDQBBNPISA-N
  • SMILES: N#C/C(C#N)=C(N)/C(C#N)=C\C1=CC=C(NC=C2)C2=C1

Biological Activity: AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM). AG 370 displays weak inhibition of the EGF receptor[1].

Cat. No. Product Name Purity Description
HY-116111 AG 370 ≥97.0% AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM). AG 370 displays weak inhibition of the EGF receptor.

References

[1]. M C Bryckaert, et al. Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins. Exp Cell Res. 1992 Apr;199(2):255-61. [Content Brief]

Keywords:

AG 370