2. Cell Cycle/DNA Damage Epigenetics TGF-beta/Smad
  3. CDK PKC
  4. 164658-13-3

164658-13-3

CGP60474 Chemical Structure

164658-13-3

Chemical Structure

  • CGP60474
  • CAS No: 164658-13-3
    Formula: C18H18ClN5O
    Molecular Weight: 355.82
  • IUPAC Name: 3-((4-(2-((3-chlorophenyl)amino)pyrimidin-4-yl)pyridin-2-yl)amino)propan-1-ol
  • InChIKey: IYNDTACKOAXKBJ-UHFFFAOYSA-N
  • SMILES: ClC1=CC(NC2=NC=CC(C3=CC=NC(NCCCO)=C3)=N2)=CC=C1

Biological Activity: CGP60474, a highly potent anti-endotoxemic agent, is a potent cyclin-dependent kinase (CDK) inhibitor (IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/B, CDK2/E, CDK2/A, CDK4/D, CDK5/p25, CDK7/H and CDK9/T, respectively). CGP60474 is a selective and ATP-competitive PKC inhibitor[1][2][3].

Cat. No. Product Name Purity Description
HY-11009 CGP60474 99.23% CGP60474, a highly potent anti-endotoxemic agent, is a potent cyclin-dependent kinase (CDK) inhibitor (IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/B, CDK2/E, CDK2/A, CDK4/D, CDK5/p25, CDK7/H and CDK9/T, respectively). CGP60474 is a selective and ATP-competitive PKC inhibitor.

References

[1]. Jorda R, et al. How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?. J Med Chem. 2018;61(20):9105-9120. [Content Brief]
[2]. Han HW, et al. LINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agent. Sci Rep. 2018;8(1):14969. Published 2018 Oct 8. [Content Brief]
[3]. Stanetty P, et al. Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy. J Org Chem. 2005;70(13):5215-5220. [Content Brief]

Keywords:

CGP60474