2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. 1660963-42-7

1660963-42-7

Olafertinib Chemical Structure

1660963-42-7

Chemical Structure

  • Olafertinib
  • CAS No: 1660963-42-7
    Formula: C29H28F2N6O2
    Molecular Weight: 530.57
  • IUPAC Name: N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide
  • InChIKey: IDRGFNPZDVBSSE-UHFFFAOYSA-N
  • SMILES: OCCN1CCN(C2=C(F)C(F)=C(NC3=NC=C4C(C(C5=CC(NC(C=C)=O)=CC=C5)=CC=C4)=N3)C=C2)CC1

Biological Activity: Olafertinib is a third-generation EGFR TKI, with GI50 values of 5 nM (EGFR L858R/T790M), 10 nM (EGFR del19) and 689 nM (EGFR WT), respectively. Olafertinib has the potential for NSCLC research[1].

Cat. No. Product Name Purity Description
HY-19815 Olafertinib 99.51% Olafertinib is a third-generation EGFR TKI, with GI50 values of 5 nM (EGFR L858R/T790M), 10 nM (EGFR del19) and 689 nM (EGFR WT), respectively. Olafertinib has the potential for NSCLC research.

References

[1]. Misako Nagasaka, et al. Beyond osimertinib: The development of 3 rd-generation EGFR Tyrosine Kinase Inhibitors. J Thorac Oncol. 2020 Dec 15;S1556-0864(20)31105-9. [Content Brief]

Keywords:

Olafertinib