2. Others
  3. Drug Intermediate
  4. 2757963-81-6

2757963-81-6

HCV-IN-36 Chemical Structure

2757963-81-6

Chemical Structure

  • HCV-IN-36
  • CAS No: 2757963-81-6
    Formula: C30H36ClN5
    Molecular Weight: 502.09
  • IUPAC Name: (S)-2-((4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)methyl)-4-((2-(dimethylamino)ethyl)(methyl)amino)benzonitrile
  • InChIKey: JIVUWMJTYLABHA-PMERELPUSA-N
  • SMILES: N#CC(C=CC(N(C)CCN(C)C)=C1)=C1CN(CC2)CCN2[C@@H](C3=CC=CC=C3)C4=CC=C(C=C4)Cl

Biological Activity: HCV-IN-36 (compound (S)-3h) is an orally active and potent HCV entry inhibitor. HCV-IN-36 shows excellent antiviral activity, with an EC50 of 0.016 μM and a CC50 (half-maximal cytotoxic concentration) of 8.78 μM[1].

Cat. No. Product Name Purity Description
HY-144109 HCV-IN-36 HCV-IN-36 (compound (S)-3h) is an orally active and potent HCV entry inhibitor. HCV-IN-36 shows excellent antiviral activity, with an EC50 of 0.016 μM and a CC50 (half-maximal cytotoxic concentration) of 8.78 μM.

References

[1]. Wang Y, Li J, Tan J, Yang B, Quan Y, Peng Z, Li Y, Li Z. Design, Synthesis, and Biological Evaluation of 2-((4-Bisarylmethyl-piperazin-1-yl)methyl)benzonitrile Derivatives as HCV Entry Inhibitors. J Med Chem. 2022 Feb 10;65(3):2107-2121. [Content Brief]

Keywords:

HCV-IN-36