2. Epigenetics
  3. Epigenetic Reader Domain
  4. 1665195-94-7

1665195-94-7

BAZ2-ICR Chemical Structure

1665195-94-7

Chemical Structure

  • BAZ2-ICR
  • CAS No: 1665195-94-7
    Formula: C20H19N7
    Molecular Weight: 357.41
  • IUPAC Name: 4-(4-(1-methyl-1H-pyrazol-4-yl)-1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-imidazol-5-yl)benzonitrile
  • InChIKey: RRZVGDGTWNQAPW-UHFFFAOYSA-N
  • SMILES: N#CC1=CC=C(C2=C(C3=CN(C)N=C3)N=CN2CCC4=CN(C)N=C4)C=C1

Biological Activity: BAZ2-ICR is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM and 180 nM, and Kds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains. BAZ2-ICR is an epigenetic chemical probe[1].

Cat. No. Product Name Purity Description
HY-19336 BAZ2-ICR 99.95% BAZ2-ICR is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM and 180 nM, and Kds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains. BAZ2-ICR is an epigenetic chemical probe.

References

[1]. Drouin L, et al. Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B. J Med Chem. 2015 Mar 12;58(5):2553-9. [Content Brief]

Keywords:

BAZ2-ICR