2. PI3K/Akt/mTOR
  3. mTOR
  4. 1685280-21-0

1685280-21-0

mTOR inhibitor-23 Chemical Structure

1685280-21-0

Chemical Structure

  • mTOR inhibitor-23
  • CAS No: 1685280-21-0
    Formula: C15H8Br3NO3
    Molecular Weight: 489.94
  • IUPAC Name: 6,8-dibromo-2-(4-bromophenyl)-3-nitro-2H-chromene
  • InChIKey: CYEGQBKPPSAVKF-UHFFFAOYSA-N
  • SMILES: BrC(C=C1)=CC=C1C2OC3=C(Br)C=C(Br)C=C3C=C2[N+]([O-])=O

Biological Activity: mTOR inhibitor-23 (compound DHM25) is a selective, competitive, irreversible and covalent inhibitor of mTOR. mTOR inhibitor-23 has the mechanism of inhibition occurs mainly through its capacity to covalently interact with a nucleophilic amino acid inside the ATP pocket. mTOR inhibitor-23 exerts potent antitumor activity against triple-negative breast tumor cell lines[1].

Cat. No. Product Name Purity Description
HY-18953 mTOR inhibitor-23 mTOR inhibitor-23 (compound DHM25) is a selective, competitive, irreversible and covalent inhibitor of mTOR. mTOR inhibitor-23 has the mechanism of inhibition occurs mainly through its capacity to covalently interact with a nucleophilic amino acid inside the ATP pocket. mTOR inhibitor-23 exerts potent antitumor activity against triple-negative breast tumor cell lines.

References

[1]. Amélie Fouqué, et al. A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells. J Med Chem. 2015 Aug 27;58(16):6559-73. [Content Brief]

Keywords:

mTOR inhibitor-23