2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. 28532-21-0

28532-21-0

MC4033 Chemical Structure

28532-21-0

Chemical Structure

  • MC4033
  • CAS No: 28532-21-0
    Formula: C16H13N3O3
    Molecular Weight: 295.29
  • InChIKey: WBHVGUYXAZIVHV-ZROIWOOFSA-N
  • SMILES: CC1=NN(C2=CC=C(C=C2)C(O)=O)C(/C1=C\C3=CC=CN3)=O

Biological Activity: MC4033 shows IC50s of 39.4 μM, 52.1 μM, 41 μM and 30.1 μM in HCT116, H1299, A549 and U937, respectively[1].
MC4033 (25, 50, 100, and 200 μM, 72 h) reduces the level of H4K16Ac in HT29 cells, suggesting its ability to inhibit KAT8 in cells[1].

Cat. No. Product Name Purity Description
HY-149302 MC4033 99.77% MC4033 shows IC50s of 39.4 μM, 52.1 μM, 41 μM and 30.1 μM in HCT116, H1299, A549 and U937, respectively.
MC4033 (25, 50, 100, and 200 μM, 72 h) reduces the level of H4K16Ac in HT29 cells, suggesting its ability to inhibit KAT8 in cells.

References

[1]. Fiorentino F, et al. First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8. J Med Chem. 2023 May 25;66(10):6591-6616 [Content Brief]

Keywords:

MC4033