2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. 175205-09-1

175205-09-1

KG-548 Chemical Structure

175205-09-1

Chemical Structure

  • KG-548
  • CAS No: 175205-09-1
    Formula: C9H4F6N4
    Molecular Weight: 282.15
  • IUPAC Name: 5-(3,5-bis(trifluoromethyl)phenyl)-1H-tetrazole
  • InChIKey: KKJFZIQEWZVVIV-UHFFFAOYSA-N
  • SMILES: FC(C1=CC(C(F)(F)F)=CC(C2=NN=NN2)=C1)(F)F

Biological Activity: KG-548 is an ARNT/TACC3 disruptor and a HIF-1α inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as HIF-β[1][2].

Cat. No. Product Name Purity Description
HY-120087 KG-548 99.92% KG-548 is an ARNT/TACC3 disruptor and a HIF-1α inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as HIF-β.

References

[1]. Guo Y, et al. Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. ACS Chem Biol. 2013 Mar 15;8(3):626-35. [Content Brief]
[2]. Kleszcz R, et al. The inhibition of c-MYC transcription factor modulates the expression of glycolytic and glutaminolytic enzymes in FaDu hypopharyngeal carcinoma cells. Adv Clin Exp Med. 2018 Jun;27(6):735-742. [Content Brief]

Keywords:

KG-548