2. Anti-infection
  3. VSV Antibiotic
  4. 865488-53-5

865488-53-5

DM-NOFD Chemical Structure

865488-53-5

Chemical Structure

  • DM-NOFD
  • CAS No: 865488-53-5
    Formula: C13H15NO5
    Molecular Weight: 265.26
  • IUPAC Name: methyl (2-methoxy-2-oxoacetyl)-D-phenylalaninate
  • InChIKey: CAUUPQLNYYFMOQ-SNVBAGLBSA-N
  • SMILES: COC(C(N[C@@H](C(OC)=O)CC1=CC=CC=C1)=O)=O

Biological Activity: DM-NOFD is a cell penetrant, prodrug of NOFD a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF)[1][2].

Cat. No. Product Name Purity Description
HY-112068 DM-NOFD DM-NOFD is a cell penetrant, prodrug of NOFD a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF).

References

[1]. Luczak MW, Krawic C, Zhitkovich A. NAD+ metabolism controls growth inhibition by HIF1 in normoxia and determines differential sensitivity of normal and cancer cells. Cell Cycle. 2021 Sep;20(18):1812-1827. [Content Brief]
[2]. Corner TP, et al. Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α. Chem Sci. 2023 Oct 27;14(43):12098-12120. [Content Brief]

Keywords:

DM-NOFD