2. Others Metabolic Enzyme/Protease
  3. Drug Metabolite Isotope-Labeled Compounds
  4. 58142-99-7

58142-99-7

DSRM-3716 Chemical Structure

58142-99-7

Chemical Structure

  • DSRM-3716
  • Synonym(s): 5-Iodoisoquinoline
  • CAS No: 58142-99-7
    Formula: C9H6IN
    Molecular Weight: 255.06
  • IUPAC Name: 5-iodoisoquinoline
  • InChIKey: CUILFTFMBBGSFT-UHFFFAOYSA-N
  • SMILES: IC1=CC=CC2=C1C=CN=C2

Biological Activity: DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. DSRM-3716 is selective against other NAD+-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection[1].

Cat. No. Product Name Purity Description
HY-W021879 DSRM-3716 99.91% DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. DSRM-3716 is selective against other NAD+-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection.

References

[1]. Robert O Hughes, et al. Small Molecule SARM1 Inhibitors Recapitulate the SARM1 -/- Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate. Cell Rep. 2021 Jan 5;34(1):108588. [Content Brief]

Keywords:

DSRM-3716