2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. 1804978-81-1

1804978-81-1

YNT-185 Chemical Structure

1804978-81-1

Chemical Structure

  • YNT-185
  • CAS No: 1804978-81-1
    Formula: C33H37N5O5S
    Molecular Weight: 615.74
  • IUPAC Name: 3'-(N-(3-((2-(2-(dimethylamino)benzamido)ethyl)amino)phenyl)sulfamoyl)-4'-methoxy-N,N-dimethyl-[1,1'-biphenyl]-3-carboxamide
  • InChIKey: BXJSAMKIFDDLGI-UHFFFAOYSA-N
  • SMILES: O=C(C1=CC(C2=CC=C(OC)C(S(=O)(NC3=CC=CC(NCCNC(C4=CC=CC=C4N(C)C)=O)=C3)=O)=C2)=CC=C1)N(C)C

Biological Activity: YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models[1][2].

Cat. No. Product Name Purity Description
HY-136181A YNT-185 98.36% YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models.

References

[1]. Nagahara T, et al. Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists. J Med Chem. 2015;58(20):7931-7937. [Content Brief]
[2]. Irukayama-Tomobe Y, et al. Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc Natl Acad Sci U S A. 2017;114(22):5731-5736. [Content Brief]

Keywords:

YNT-185