2. Metabolic Enzyme/Protease
  3. Lactate Dehydrogenase
  4. 1802977-61-2

1802977-61-2

GNE-140 racemate Chemical Structure

1802977-61-2

Chemical Structure

  • GNE-140 racemate
  • CAS No: 1802977-61-2
    Formula: C25H23ClN2O3S2
    Molecular Weight: 499.04
  • IUPAC Name: 3-((2-chlorophenyl)thio)-6-(4-morpholinophenyl)-6-(thiophen-3-yl)piperidine-2,4-dione
  • InChIKey: GLDDJXYFHWRGPI-UHFFFAOYSA-N
  • SMILES: O=C(C1SC2=CC=CC=C2Cl)NC(C3=CSC=C3)(C4=CC=C(N5CCOCC5)C=C4)CC1=O

Biological Activity: GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor[1][2].

Cat. No. Product Name Purity Description
HY-100742 GNE-140 racemate 99.38% GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor.

References

[1]. Ždralević M, et al. Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism. J Biol Chem. 2018 Oct 12;293(41):15947-15961. [Content Brief]
[2]. Purkey HE, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett. 2016 Aug 26;7(10):896-901. [Content Brief]

Keywords:

GNE-140 racemate