2. GPCR/G Protein
  3. LPL Receptor
  4. 1807873-14-8

1807873-14-8

KSI-6666 Chemical Structure

1807873-14-8

Chemical Structure

  • KSI-6666
  • CAS No: 1807873-14-8
    Formula: C23H26ClF3N2O2
    Molecular Weight: 454.91
  • InChIKey: CEBVCUSXXIVBGX-UHFFFAOYSA-N
  • SMILES: CCN(C(C1=CC=C(C(CN2CC(C2)C(O)=O)=C1)C)C)C3=CC=C(C(C(F)(F)F)=C3)Cl

Biological Activity: KSI-6666 is an orally active, competitive antagonist for sphingosine 1-phosphate receptor 1 (S1PR1), with an IC50 of 6.4 nM. KSI-6666 exhibits anti-inflammatory efficacy in autoimmune encephalomyelitis model and T cell transfer colitis model[1].

Cat. No. Product Name Purity Description
HY-158417 KSI-6666 KSI-6666 is an orally active, competitive antagonist for sphingosine 1-phosphate receptor 1 (S1PR1), with an IC50 of 6.4 nM. KSI-6666 exhibits anti-inflammatory efficacy in autoimmune encephalomyelitis model and T cell transfer colitis model.

References

[1]. Maruyama Y, et al. Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonist[J]. bioRxiv, 2023: 2023.05. 08.539826.

Keywords:

KSI-6666