2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. 2725075-04-5

2725075-04-5

Chitin synthase inhibitor 11 Chemical Structure

2725075-04-5

Chemical Structure

  • Chitin synthase inhibitor 11
  • CAS No: 2725075-04-5
    Formula: C24H24N4O8
    Molecular Weight: 496.47
  • IUPAC Name: (E)-4-(6-methoxy-2-oxo-1,2-dihydrospiro[benzo[d][1,3]oxazine-4,4'-piperidin]-1'-yl)-N-(2-methoxy-4-nitrophenyl)-4-oxobut-2-enamide
  • InChIKey: HVTXVBKBVDRHEG-BQYQJAHWSA-N
  • SMILES: O=C(NC1=CC=C([N+]([O-])=O)C=C1OC)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O

Biological Activity: Chitin synthase inhibitor 11 is a chitin synthase inhibitor. Chitin synthase inhibitor 11 shows excellent chitin synthase inhibitory activity with an IC50 value of 0.10 mM. Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro. Chitin synthase inhibitor 11 can be used for the research of invasive fungal infections (IFIs)[1].

Cat. No. Product Name Purity Description
HY-151421 Chitin synthase inhibitor 11 Chitin synthase inhibitor 11 is a chitin synthase inhibitor. Chitin synthase inhibitor 11 shows excellent chitin synthase inhibitory activity with an IC50 value of 0.10 mM. Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro. Chitin synthase inhibitor 11 can be used for the research of invasive fungal infections (IFIs).

References

[1]. Yajie Xu, et al. Spiro[benzoxazine-piperidin]-one derivatives as chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation. Eur J Med Chem. 2022 Aug 31;243:114723 [Content Brief]

Keywords:

Chitin synthase inhibitor 11