2. Epigenetics TGF-beta/Smad Cell Cycle/DNA Damage
  3. PKC Nucleoside Antimetabolite/Analog
  4. 60559-98-0

60559-98-0

P-1075 Chemical Structure

60559-98-0

Chemical Structure

  • P-1075
  • CAS No: 60559-98-0
    Formula: C12H17N5
    Molecular Weight: 231.30
  • InChIKey: HKZNADVVGXKQDL-UHFFFAOYSA-N
  • SMILES: CCC(N/C(NC#N)=N/C1=CC=CN=C1)(C)C

Biological Activity: P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation[1]. P-1075 also P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts[2].

Cat. No. Product Name Purity Description
HY-108573 P-1075 99.81% P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation. P-1075 also P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.

References

[1]. Schwanstecher M, et al. Potassium channel openers require ATP to bind to and act through sulfonylurea receptors. EMBO J. 1998 Oct 1;17(19):5529-35. [Content Brief]
[2]. Oldenburg O, et al. P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts. J Mol Cell Cardiol. 2003 Sep;35(9):1035-42. [Content Brief]

Keywords:

P-1075