2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. 886041-60-7

886041-60-7

MK3281 Chemical Structure

886041-60-7

Chemical Structure

  • MK3281
  • CAS No: 886041-60-7
    Formula: C29H37N3O3
    Molecular Weight: 475.62
  • IUPAC Name: (R)-14-cyclohexyl-7-((2-(dimethylamino)ethyl)(methyl)amino)-7,8-dihydro-6H-benzo[2,3][1,5]oxazocino[5,4-a]indole-11-carboxylic acid
  • InChIKey: YQUCBFIQSJVCOR-JOCHJYFZSA-N
  • SMILES: CN(C)CCN([C@@H]1CN2C(C3=CC=CC=C3OC1)=C(C4CCCCC4)C5=CC=C(C(O)=O)C=C52)C

Biological Activity: MK3281 (Compound 33) is a non-nucleoside hepatitis C virus (HCV) NS5B polymerase inhibitor, with an EC50 of 28 nM for gt1a[1].

Cat. No. Product Name Purity Description
HY-111204 MK3281 MK3281 (Compound 33) is a non-nucleoside hepatitis C virus (HCV) NS5B polymerase inhibitor, with an EC50 of 28 nM for gt1a.

References

[1]. Narjes F, et al. Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase. J Med Chem. 2011 Jan 13;54(1):289-301. [Content Brief]

Keywords:

MK3281