2. Others Metabolic Enzyme/Protease
  3. Fluorescent Dye MMP
  4. 892742-76-6

892742-76-6

UT-B-IN-1 Chemical Structure

892742-76-6

Chemical Structure

  • UT-B-IN-1
  • CAS No: 892742-76-6
    Formula: C20H17N5O2S3
    Molecular Weight: 455.58
  • IUPAC Name: 3-((4-ethylphenyl)sulfonyl)-N-(thiophen-2-ylmethyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine
  • InChIKey: UYFZCWXRMHSLTC-UHFFFAOYSA-N
  • SMILES: O=S(C1=C2N=C(NCC3=CC=CS3)C4=C(C=CS4)N2N=N1)(C5=CC=C(CC)C=C5)=O

Biological Activity: UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research[1].

Cat. No. Product Name Purity Description
HY-128129 UT-B-IN-1 99.68% UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research.

References

[1]. Yao C, et al. Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration. J Am Soc Nephrol. 2012 Jul;23(7):1210-20. [Content Brief]

Keywords:

UT-B-IN-1