2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. 1350752-07-6

1350752-07-6

G9a-IN-1 Chemical Structure

1350752-07-6

Chemical Structure

  • G9a-IN-1
  • CAS No: 1350752-07-6
    Formula: C24H36ClN5O2
    Molecular Weight: 462.03
  • IUPAC Name: 2-chloro-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine
  • InChIKey: GHTIAKXLWWMKSI-UHFFFAOYSA-N
  • SMILES: CC(N1CCC(NC2=C3C=C(OC)C(OCCCN4CCCC4)=CC3=NC(Cl)=N2)CC1)C

Biological Activity: G9a-IN-1 (Compound 113) is a G9a protein inhibitor. G9A/EHMT2 is a nuclear histone lysine methyltransferase that catalyzes histone H3 lysine 9 dimethylation (H3K9me2), which is a reversible modification generally associated with transcriptional gene silencing. G9a-IN-1 can be used for the research of autoimmune disorders or cancer[1].

Cat. No. Product Name Purity Description
HY-44062 G9a-IN-1 98.12% G9a-IN-1 (Compound 113) is a G9a protein inhibitor. G9A/EHMT2 is a nuclear histone lysine methyltransferase that catalyzes histone H3 lysine 9 dimethylation (H3K9me2), which is a reversible modification generally associated with transcriptional gene silencing. G9a-IN-1 can be used for the research of autoimmune disorders or cancer.

References

[1]. Dimitrios Iliopoulos, et al. Small molecules for the treatment of autoimmune diseases and cancer. WO2022031939A1

Keywords:

G9a-IN-1