2. Epigenetics TGF-beta/Smad Cytoskeleton Cell Cycle/DNA Damage Stem Cell/Wnt
  3. PKC ROCK
  4. 1941168-71-3

1941168-71-3

CMPD101 hydrochloride Chemical Structure

1941168-71-3

Chemical Structure

  • CMPD101 hydrochloride
  • CAS No: 1941168-71-3
    Formula: C24H22ClF3N6O
    Molecular Weight: 502.92
  • IUPAC Name: 3-(((4-methyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)methyl)amino)-N-(2-(trifluoromethyl)benzyl)benzamide hydrochloride
  • InChIKey: QBLGBXYDINNUFE-UHFFFAOYSA-N
  • SMILES: O=C(C1=CC(NCC2=NN=C(C3=CC=NC=C3)N2C)=CC=C1)NCC4=CC=CC=C4C(F)(F)F.[H]Cl

Biological Activity: CMPD101 hydrochloride is a novel membrane-permeable, small-molecule inhibitor of both GRK2 and GRK3 with IC50s of 18 nM and 5.4 nM, respectively. CMPD101 hydrochloride also inhibits Rho-associated kinase 2 (ROCK-2) and PKCα (IC50s =1.4 μM and 8.1 μM, respectively)[1].

Cat. No. Product Name Purity Description
HY-103045A CMPD101 hydrochloride CMPD101 hydrochloride is a novel membrane-permeable, small-molecule inhibitor of both GRK2 and GRK3 with IC50s of 18 nM and 5.4 nM, respectively. CMPD101 hydrochloride also inhibits Rho-associated kinase 2 (ROCK-2) and PKCα (IC50s =1.4 μM and 8.1 μM, respectively).

References

[1]. Okawa T, et al. Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure. J Med Chem. 2017 Aug 24;60(16):6942-6990. [Content Brief]

Keywords:

CMPD101 hydrochloride