2. PROTAC Autophagy Apoptosis
  3. E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis
  4. 1950635-15-0

1950635-15-0

Thalidomide-O-amido-C8-NH2 Chemical Structure

1950635-15-0

Chemical Structure

  • Thalidomide-O-amido-C8-NH2
  • Synonym(s): Cereblon Ligand-Linker Conjugates 2; E3 Ligase Ligand-Linker Conjugates 20
  • CAS No: 1950635-15-0
    Formula: C23H30N4O6
    Molecular Weight: 458.51
  • IUPAC Name: N-(8-aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
  • InChIKey: QTUVCTXXMOZFHS-UHFFFAOYSA-N
  • SMILES: NCCCCCCCCNC(COC1=C(C(N2C(CCC3=O)C(N3)=O)=O)C(C2=O)=CC=C1)=O

Biological Activity: Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

Cat. No. Product Name Purity Description
HY-107439 Thalidomide-O-amido-C8-NH2 Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.

References

[1]. James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.

Keywords:

Thalidomide-O-amido-C8-NH2