2. Peptides
  3. Peptide and Derivatives
  4. Inhibitors and Substrates
  5. 227619-65-0

227619-65-0

(±)-HIP-B Chemical Structure

227619-65-0

Chemical Structure

  • (±)-HIP-B
  • CAS No: 227619-65-0
    Formula: C6H8N2O4
    Molecular Weight: 172.14
  • IUPAC Name: (3aS,6S,6aS)-3-oxohexahydro-2H-pyrrolo[3,4-d]isoxazole-6-carboxylic acid
  • InChIKey: IOOKKDXVJPSSSC-HZLVTQRSSA-N
  • SMILES: OC([C@@H]1[C@]2([H])[C@@](CN1)([H])C(NO2)=O)=O

Biological Activity: (±)-HIP-B is a non-competitive excitatory amino acid transporter (EAAT) blocker that effectively blocks Glu uptake (IC50=17-18 μM). (±)-HIP-B is also a lead compound against ischemia-induced neuronal degeneration. (±)-HIP-B can be used in the study of neurological diseases[1].

Cat. No. Product Name Purity Description
HY-107524 (±)-HIP-B (±)-HIP-B is a non-competitive excitatory amino acid transporter (EAAT) blocker that effectively blocks Glu uptake (IC50=17-18 μM). (±)-HIP-B is also a lead compound against ischemia-induced neuronal degeneration. (±)-HIP-B can be used in the study of neurological diseases.

References

[1]. Andrea Pinto, et al. Synthesis of enantiomerically pure HIP-A and HIP-B and investigation of their activity as inhibitors of excitatory amino acid transporters.

Keywords:

(±)-HIP-B