2. PROTAC NF-κB
  3. PROTACs IKK
  4. 2648279-76-7

2648279-76-7

Multi-kinase inhibitor 3 Chemical Structure

2648279-76-7

Chemical Structure

  • Multi-kinase inhibitor 3
  • CAS No: 2648279-76-7
    Formula: C26H26N6O2
    Molecular Weight: 454.52
  • InChIKey: VIQAAPJVSOWKQK-UHFFFAOYSA-N
  • SMILES: CN1N=CC(C2=CC=C(N(C3=CC=C(CC(NC4=CC(C(C)(C)C)=NO4)=O)C=C3)C=N5)C5=C2)=C1

Biological Activity: Multi-kinase inhibitor 3 (compound 12) is a potent and orally active multikinase inhibitor with IC50 values of 1.59, 1.23, 1.19, 0.59, 0.22, 1.15 nM for FLT1/VEGFR1, KDR/VEGFR2, FLT4/VEGFR3, FLT3, PDGFRα, PDGFRβ, respectively. Multi-kinase inhibitor 3 shows antiproliferative activity. Multi-kinase inhibitor 3 shows anticancer activity[1].

Cat. No. Product Name Purity Description
HY-168114 Multi-kinase inhibitor 3 Multi-kinase inhibitor 3 (compound 12) is a potent and orally active multikinase inhibitor with IC50 values of 1.59, 1.23, 1.19, 0.59, 0.22, 1.15 nM for FLT1/VEGFR1, KDR/VEGFR2, FLT4/VEGFR3, FLT3, PDGFRα, PDGFRβ, respectively. Multi-kinase inhibitor 3 shows antiproliferative activity. Multi-kinase inhibitor 3 shows anticancer activity.

References

[1]. Das D, et al. Discovery of novel, orally bioavailable phenylacetamide derivatives as multikinase inhibitors and in vivo efficacy study in hepatocellular carcinoma animal models. Bioorg Med Chem Lett. 2024 Sep 19;113:129971. [Content Brief]

Keywords:

Multi-kinase inhibitor 3