2. Epigenetics Apoptosis
  3. Histone Methyltransferase Apoptosis
  4. 1541208-02-9

1541208-02-9

Tubulin inhibitor 43 Chemical Structure

1541208-02-9

Chemical Structure

  • Tubulin inhibitor 43
  • CAS No: 1541208-02-9
    Formula: C20H21NO6
    Molecular Weight: 371.38
  • InChIKey: VQAFFPQTZLYJDR-GOSISDBHSA-N
  • SMILES: O=C1N(C2=CC(OC)=C(C(OC)=C2)OC)[C@@H](C3=CC(O)=C(C=C3)OC)C1=C

Biological Activity: Tubulin inhibitor 43 (Compound 29) has significant antitumor activity. Tubulin inhibitor 43 inhibits the proliferation and growth of cancer cells by inhibiting the activity of β-microtubulin, and finally induces apoptosis[1].

References

[1]. Zhou P, et al.Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents. Eur J Med Chem. 2018 Jan 20;144:817-842.  [Content Brief]

Keywords:

Tubulin inhibitor 43