2. Membrane Transporter/Ion Channel
  3. P2X Receptor
  4. 2097117-06-9

2097117-06-9

Lu AF27139 Chemical Structure

2097117-06-9

Chemical Structure

  • Lu AF27139
  • CAS No: 2097117-06-9
    Formula: C21H19ClF3N5O2S
    Molecular Weight: 497.92
  • IUPAC Name: (S)-N-(2-(4-chlorophenyl)-2-morpholinoethyl)-2-(pyrimidin-2-yl)-4-(trifluoromethyl)thiazole-5-carboxamide
  • InChIKey: FGPQIEDRTXLBES-OAHLLOKOSA-N
  • SMILES: ClC(C=C1)=CC=C1[C@H](N2CCOCC2)CNC(C3=C(C(F)(F)F)N=C(C4=NC=CC=N4)S3)=O

Biological Activity: Lu AF27139 is a potent, selective, and orally active antagonist of P2X7 receptor (IC50s of 12 and 2.4 nM for human and rat, Kis of 22, 54, and 13 nM for mouse, human, and rat, respectively). Lu AF27139 has rodent-active and CNS-penetrant character. Lu AF27139 has the potential for the research of CNS diseases[1].

Cat. No. Product Name Purity Description
HY-132981 Lu AF27139 99.71% Lu AF27139 is a potent, selective, and orally active antagonist of P2X7 receptor (IC50s of 12 and 2.4 nM for human and rat, Kis of 22, 54, and 13 nM for mouse, human, and rat, respectively). Lu AF27139 has rodent-active and CNS-penetrant character. Lu AF27139 has the potential for the research of CNS diseases.

References

[1]. Hopper AT, et al. Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139. J Med Chem. 2021 Apr 22;64(8):4891-4902. [Content Brief]

Keywords:

Lu AF27139