2. PROTAC
  3. PROTAC Linkers
  4. 2112737-60-5

2112737-60-5

N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) Chemical Structure

2112737-60-5

Chemical Structure

  • N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl)
  • CAS No: 2112737-60-5
    Formula: C29H52N2O11
    Molecular Weight: 604.73
  • IUPAC Name: tert-butyl ((9-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)-3,6,12,15,18-pentaoxa-9-azahenicos-20-yn-1-yl)oxy)carbamate
  • InChIKey: WPRVFLKXCQXMJG-UHFFFAOYSA-N
  • SMILES: C#CCOCCOCCOCCN(CCOCCOCCOCC#C)CCOCCOCCONC(OC(C)(C)C)=O

Biological Activity: N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No. Product Name Purity Description
HY-140092 N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Keywords:

N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl)