2. Epigenetics
  3. Protein Arginine Deiminase
  4. 2205846-49-5

2205846-49-5

BMS905 Chemical Structure

2205846-49-5

Chemical Structure

  • BMS905
  • CAS No: 2205846-49-5
    Formula: C23H29N3
    Molecular Weight: 347.50
  • IUPAC Name: 2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole
  • InChIKey: XSXCQWXAFRASGU-UHFFFAOYSA-N
  • SMILES: CC1=NC(C)=CC(C2=C(C(C)C)C3=C(C=CC(C4CCNCC4)=C3)N2)=C1

Biological Activity: BMS905 is an orally active TLR7 and TLR8 dual inhibitor (IC50s: 0.7 and 3.2 nM respectively). BMS905 inhibits TLR7 or TLR8 induced IL-6 production in human/mouse whole blood. BMS905 can be used for research of lupus[1].

Cat. No. Product Name Purity Description
HY-153254 BMS905 99.59% BMS905 is an orally active TLR7 and TLR8 dual inhibitor (IC50s: 0.7 and 3.2 nM respectively). BMS905 inhibits TLR7 or TLR8 induced IL-6 production in human/mouse whole blood. BMS905 can be used for research of lupus.

References

[1]. Sreekantha RK, et al. Identification of 2-Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8). ACS Med Chem Lett. 2022 Apr 25;13(5):812-818. [Content Brief]

Keywords:

BMS905