2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. 2410557-00-3

2410557-00-3

iRucaparib-AP6 Chemical Structure

2410557-00-3

Chemical Structure

  • iRucaparib-AP6
  • CAS No: 2410557-00-3
    Formula: C46H55FN6O11
    Molecular Weight: 886.96
  • IUPAC Name: 2-(2,6-dioxopiperidin-3-yl)-4-((1-(4-(8-fluoro-1-oxo-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-5-yl)phenyl)-2-methyl-5,8,11,14,17,20-hexaoxa-2-azadocosan-22-yl)amino)isoindoline-1,3-dione
  • InChIKey: YHMDCINUVWULST-UHFFFAOYSA-N
  • SMILES: O=C(NCC1)C2=CC(F)=CC3=C2C1=C(C4=CC=C(C=C4)CN(CCOCCOCCOCCOCCOCCOCCNC5=CC=CC(C(N6C7CCC(NC7=O)=O)=O)=C5C6=O)C)N3

Biological Activity: iRucaparib-AP6 is a highly efficient and specific PROTAC PARP1 degrader. iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1[1].

References

[1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation.Nat Chem Biol. 2019 Dec;15(12):1223-1231. [Content Brief]

Keywords:

iRucaparib-AP6