2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. 1438881-19-6

1438881-19-6

CRT0066854 Chemical Structure

1438881-19-6

Chemical Structure

  • CRT0066854
  • CAS No: 1438881-19-6
    Formula: C24H25N5S
    Molecular Weight: 415.55
  • IUPAC Name: (S)-3-phenyl-N1-(2-(pyridin-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)propane-1,2-diamine
  • InChIKey: NRHASZRDWOUMFD-SFHVURJKSA-N
  • SMILES: N[C@H](CNC1=NC(C2=CC=NC=C2)=NC3=C1C(CCCC4)=C4S3)CC5=CC=CC=C5

Biological Activity: CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively[1].

Cat. No. Product Name Purity Description
HY-18713 CRT0066854 99.00% CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively.

References

[1]. Kjær S, et al. Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem J. 2013 Apr 15;451(2):329-42. [Content Brief]

Keywords:

CRT0066854