2. Immunology/Inflammation
  3. Interleukin Related
  4. 1903008-80-9

1903008-80-9

Lazertinib Chemical Structure

1903008-80-9

Chemical Structure

  • Lazertinib
  • Synonym(s): YH25448; GNS-1480
  • CAS No: 1903008-80-9
    Formula: C30H34N8O3
    Molecular Weight: 554.64
  • IUPAC Name: N-(5-((4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide
  • InChIKey: RRMJMHOQSALEJJ-UHFFFAOYSA-N
  • SMILES: C=CC(NC1=CC(NC2=NC=CC(N3N=C(C4=CC=CC=C4)C(CN(C)C)=C3)=N2)=C(OC)C=C1N5CCOCC5)=O

Biological Activity: Lazertinib (YH25448) is a potent, highly mutant-selective, blood-brain barrier permeable, orally available and irreversible third-generation EGFR tyrosine kinase inhibitor, and can be used in the research of non-small cell lung cancer[1].

Cat. No. Product Name Purity Description
HY-109061 Lazertinib 99.87% Lazertinib (YH25448) is a potent, highly mutant-selective, blood-brain barrier permeable, orally available and irreversible third-generation EGFR tyrosine kinase inhibitor, and can be used in the research of non-small cell lung cancer.

References

[1]. Byoung Chul Cho, et al. YH25448, a 3rd Generation EGFR-TKI, in Patients with EGFR-TKI-resistant NSCLC: Phase I/II Study Results.

Keywords:

Lazertinib