2. PROTAC Autophagy Apoptosis
  3. E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis
  4. 2245697-87-2

2245697-87-2

Thalidomide-PEG2-C2-NH2 hydrochloride Chemical Structure

2245697-87-2

Chemical Structure

  • Thalidomide-PEG2-C2-NH2 hydrochloride
  • Synonym(s): Thalidomide-NH-PEG2-C2-NH2 hydrochloride
  • CAS No: 2245697-87-2
    Formula: C19H25ClN4O6
    Molecular Weight: 440.88
  • IUPAC Name: 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
  • InChIKey: BIBZEYIXXZHGNZ-UHFFFAOYSA-N
  • SMILES: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCN)=O.[H]Cl

Biological Activity: Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].

Cat. No. Product Name Purity Description
HY-129703B Thalidomide-PEG2-C2-NH2 hydrochloride 98.89% Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.

References

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163. [Content Brief]

Keywords:

Thalidomide-PEG2-C2-NH2 hydrochloride