2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. 1640294-30-9

1640294-30-9

ASP4132 Chemical Structure

1640294-30-9

Chemical Structure

  • ASP4132
  • CAS No: 1640294-30-9
    Formula: C46H51F3N6O8S2
    Molecular Weight: 937.06
  • IUPAC Name: (6-(1-((6-methoxypyridin-3-yl)methyl)piperidin-4-yl)-1H-benzo[d]imidazol-2-yl)(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl)methanone bis(4-methylbenzenesulfonate)
  • InChIKey: KDMGCEXVMOJAAC-UHFFFAOYSA-N
  • SMILES: O=C(C1=NC2=CC=C(C3CCN(CC4=CC=C(OC)N=C4)CC3)C=C2N1)N5CCN(CC6=CC=C(C(F)(F)F)C=C6)CC5.O=S(C7=CC=C(C)C=C7)(O)=O.O=S(C8=CC=C(C)C=C8)(O)=O

Biological Activity: ASP4132 is an orally active, potent AMPK activator with an EC50 of 18 nM. ASP4132 has anti-cancer activity and makes tumor regression in breast cancer xenograft mouse models[1].

Cat. No. Product Name Purity Description
HY-136447 ASP4132 99.32% ASP4132 is an orally active, potent AMPK activator with an EC50 of 18 nM. ASP4132 has anti-cancer activity and makes tumor regression in breast cancer xenograft mouse models.

References

[1]. Kazuyuki Kuramoto, et al. Development of a Potent and Orally Active Activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK), ASP4132, as a Clinical Candidate for the Treatment of Human Cancer. Bioorg Med Chem. 2020 Mar 1;28(5):115307. [Content Brief]

Keywords:

ASP4132