2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. 201939-40-4

201939-40-4

PTAC oxalate Chemical Structure

201939-40-4

Chemical Structure

  • PTAC oxalate
  • CAS No: 201939-40-4
    Formula: C14H21N3O4S2
    Molecular Weight: 359.46
  • IUPAC Name: 3-((1R,5R,6R)-1-azabicyclo[3.2.1]octan-6-yl)-4-(propylthio)-1,2,5-thiadiazole oxalate
  • InChIKey: LXXQOVMTAFXOKQ-IYPAPVHQSA-N
  • SMILES: CCCSC1=NSN=C1[C@@H]2[C@@H]3C[N@@](CCC3)C2.OC(C(O)=O)=O

Biological Activity: PTAC oxalate is a selective muscarinic receptor ligand. PTAC oxalate is an partial agonist of M2 and M4 but antagonist of M1, M3, and M5 (Ki values of 0.2-2.8 nM for hM1-5 in CHO cells). PTAC oxalate alleviates the mechanical allodynia on the neuropathic pain and has antidepression effects[1][2].

Cat. No. Product Name Purity Description
HY-107656 PTAC oxalate PTAC oxalate is a selective muscarinic receptor ligand. PTAC oxalate is an partial agonist of M2 and M4 but antagonist of M1, M3, and M5 (Ki values of 0.2-2.8 nM for hM1-5 in CHO cells). PTAC oxalate alleviates the mechanical allodynia on the neuropathic pain and has antidepression effects.

References

[1]. F P Bymaster, et al. Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane. Eur J Pharmacol. 1998 Sep 4;356(2-3):109-19. [Content Brief]
[2]. (5R,6R)6-(3-Propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1] Octane on a Mouse Model of Neuropathic Pain. Anesth Analg. 2017 Apr;124(4):1330-1338. [Content Brief]

Keywords:

PTAC oxalate