2315450-35-0

Chemical Structure

Kv7.2/Kv7.3 agonist 1
CAS No: 2315450-35-0

Formula: C₁₄H₁₄FN₃O₂

Molecular Weight: 275.28
SMILES: CC(NC1=NC(OCC2=CC=C(F)C=C2)=CC=C1N)=O

Biological Activity: Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally active agonist for KV7.2/7.3 channel (KCNQ2/3) with an EC₅₀ of 1.03 μM. Kv7.2/Kv7.3 agonist 1 exhibits analgesic efficacy in mice chronic constriction injury (CCI) model and mice Streptozotocin (HY-13753)-induced diabetic peripheral neuropathic pain (DPNP) model, with ED₅₀ of 12.02 and 9.63 mg/kg^[1].

Cat. No.	Product Name	Purity	Description
HY-168214	Kv7.2/Kv7.3 agonist 1		Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally active agonist for KV7.2/7.3 channel (KCNQ2/3) with an EC₅₀ of 1.03 μM. Kv7.2/Kv7.3 agonist 1 exhibits analgesic efficacy in mice chronic constriction injury (CCI) model and mice Streptozotocin (HY-13753)-induced diabetic peripheral neuropathic pain (DPNP) model, with ED₅₀ of 12.02 and 9.63 mg/kg.

References

[1]. Qian K, et al., Discovery of a novel KV7.2/7.3 channels agonist for the treatment of neuropathic pain. Eur J Med Chem. 2024 Oct 12;280:116953. [Content Brief]

Keywords:

Kv7.2/Kv7.3 agonist 1

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