2. PI3K/Akt/mTOR Autophagy
  3. PI3K mTOR Autophagy
  4. 1370510-16-9

1370510-16-9

Langkamide Chemical Structure

1370510-16-9

Chemical Structure

  • Langkamide
  • CAS No: 1370510-16-9
    Formula: C16H17NO5
    Molecular Weight: 303.31
  • IUPAC Name: (Z)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-1,5-dihydro-2H-pyrrol-2-one
  • InChIKey: RZTXFCPQEOFMDN-SREVYHEPSA-N
  • SMILES: COC1=C(C(OC)=CC(/C=C\C(N2C(C=CC2)=O)=O)=C1)OC

Biological Activity: Langkamide is a novel hypoxia-inducible factor-2 (HIF-2) inhibitory pyrrolidone alkaloid isolated from the roots and stems of Piper sarmentosum, which inhibits HIF-2 transcriptional activity with an EC value of 14.0μM.

Keywords:

Langkamide